Not known Details About https://www.ceesdekker.net
Not known Details About https://www.ceesdekker.net
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Employing solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions contain:
Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
Considering the fact that 2000, Dekker has shifted the key concentration of his work toward biophysics exactly where he reports the Attributes of single biomolecules and cells using the instruments of nanotechnology. This alteration of area was pushed by his fascination for that remarkable working of biological molecular constructions, together with by the lengthy-phrase viewpoint that lots of appealing discoveries could be anticipated With this subject.[five] Present-day strains of research in his biophysics group are within the areas of:[6]
That may be a dream of mine and we established to operate using a delectable dose of naivety. That is a thing that will probably generate spectacular leads to the for a longer period term, but that does not subject. You should not only want to work about the thoughts of tomorrow, but additionally about the thoughts from the working day immediately after tomorrow.’
Our analysis ranges from your biophysics of DNA to synthetic cells https://www.ceesdekker.net and past. Make sure you have a look below in the spectrum of our present tasks.
All parameters ended up exactly the same for each panel With this online video, except for the initial placement with the 6hb rod (revealed in blue) on the nanopore. Simulations that terminated early as a result of translocation on the rod from the pore are marked by a gray qualifications.
Learning DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
The rotors harness Electrical power from the nanoscale water and ion flow that may be produced by a static chemical or electrochemical likely gradient inside the nanopore, that are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological ailments, suggesting strategies to constructing Electrical power-transducing motors at nanoscale interfaces.
It had been all through this period that Dekker carried out analysis on magnetic spin programs and on sounds in superconductors and semiconductors.
Testing pseudotopological and nontopological types for SMC-driven DNA loop extrusion from roadblock-traversal experiments
Nature Physics many thanks the anonymous reviewers for their contribution to your peer overview of this get the job done.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent design and style in 2005. (nl)